This Joint Policy Brief, developed in collaboration with multiple partners and published by the NewClimate Institute, examines the EU’s emerging Clean Trade and Investment Partnerships (CTIPs), with a focus on the pilot partnership with South Africa. It analyzes how CTIPs can integrate trade, industrial policy, and climate objectives, reshape global supply chains, and foster investment in clean technologies and green industries. The brief outlines the key conditions for success, including transparency, regulatory alignment, coordinated governance, and joint ownership. It highlights the potential of the EU-South Africa CTIP to set a precedent for future strategic partnerships that advance climate, industrial, and development goals.